December 2022
Volume 10 | Issue 1&2

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Table of Contents - Year 2022 | Month: December | Volume 10 | Issue 1&2

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Editorial Editorial
  • Abstract
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    • International Journal of Bioinformatics and Biological Science welcomes the research activity of all other branches like botany, biotechnology, cytology, genetics, phytochemistry, reproductive biology, ecology, physiology, molecular biology, biodiversity, and environmental science. Hence biological science research is now a very dynamic area of science.
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Quantitative study on cellular signaling database: management and analysis of signaling network 10.30954/2319-5169.1.2022.1 Research Article
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    • The amount of information required to determine how cells interact is enormous. Block diagrams are often used to depict the complicated signaling networks that result. This is a critical step in the development of quantitative knowledge of signaling. One of the advantages of studying pathways is that it provides abundant quantitative data. Signal pathways models may be found in the Database for Quantitative Cellular Signaling. As well as serving the expanding area of chemical reaction-level signaling network modeling, it aims to foresee problems with large-scale data management in signal chemistry. The present DOQCS research uses graphical techniques and simulation in a cellular spatial framework to further this convergence. This work links database-specified route models.
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Evaluating the effectiveness of commonly used antibiotics in Pakistan 10.30954/2319-5169.1.2022.2 Research Article
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    • Antibiotic resistance and its consequences have now become a global crisis. The increasing resistance of bacteria combined with the misuse of drugs has led to an era of antibiotics that prove to be of no value to the affected individual. This raises the question of how to encounter Antimicrobial Resistance (AMR) and what reason lies behind the increasing resistance of these bacteria. This research has shown the causes of resistance due to motif combinations, identified through the literature review. The method employed was of two types, the manual type and by automation through a designed code. It exhibits that the decreasing number of motifs has shown higher resistance of bacteria. This is one of the approaches that have not been studied in detail. This would help in identifying a mutation pattern that could encounter the antibiotic effectiveness problem. The obtained results can be further validated through experimental procedures to deduce a concrete hypothesis. As a result, alternatives to the existing ineffective antibiotic can be designed in the future.
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The role of high fiber diet in the management of Type 2 diabetes: a Review on Dietetic Perspective 10.30954/2319-5169.1.2022.3 Review Article
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    • Dietary fiber is now recognized to have a profound influence on human nutrition, because of its therapeutic and beneficial effects on various states of health and diseases. Consumption of high fiber reduces the likelihood of developing cardiovascular disease, stroke, hypertension, obesity, and some gastrointestinal conditions. This review article delivers information about the role of fiber-rich foods in the management of Type 2 diabetes (T2DM). Indian Council of Medical Research (ICMR) emphasizes the importance of Medical Nutrition Therapy (MNT) in T2DM clinical practice recommendations. The benefits of a high-fiber diet, known as Fiber-rich diabetes nutrition (FDN) are improved glycaemic control, lesser glucose spikes, reduced hyperinsulinemia, better plasma lipid concentrations, and weight loss in type 2 diabetes patients. Comparing the two types of fiber (soluble and insoluble), it has been found that soluble fiber is better at lowering blood sugar, insulin, and serum lipid levels than insoluble fiber. The possible ways
    are slowing down glucose absorption, taking longer for hepatic insulin extraction, and improving insulin sensitivity. Skeletal muscle expression of the insulin-responsive glucose transporter type 4 (GLUT-4) can be influenced by diet and hence affect the body’s ability to take in glucose. This increases skeletal muscle uptake, improves insulin sensitivity, and normalizes blood sugar. Over 25 grams of fiber per day is recommended for women with type 2 diabetes, and 35 grams is recommended for males. For preventing and treating Type 2 Diabetes, it’s essential to give appropriate dietary instructions for the adequate intake of dietary fiber.
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